Sputnik V: A new warrior in the fight against Delta variant of Coronavirus in India

Sputnik V vaccine

Pilot launch for Russian vaccine against Covid19 has been extended in nine cities across India. The vaccine roll-out is slated to include other Indian cities as well. Hyderabad, Vishakapatnam, Bengaluru, Mumbai, Kolkata, Delhi, Chennai, Miyalguda, Kolhapur, and Baddi (Himachal Pradesh) are the nine cities selected for the pilot run. The pilot run in Hyderabad has been declared successful. The pilot run will test cold storage at minus 18 degrees Celsius and other related logistics. The vaccine will be rolled out in Gurugram for the first time at the Fortis Memorial Research Institute from June 19 onwards. In Haryana, Gurugram will be the first district to initiate inoculation of Sputnik V on a pilot basis.

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In an announcement on Wednesday, Dr Reddy’s lab said, “The limited pilot launch of the Sputnik V was started in Hyderabad on May 14 and is being extended to nine cities.” “The vaccine is currently in its final leg as we gear up to ensure a smooth commercial launch”, DRL had said in a statement. Gurugrams’ Fortis Institute will procure the vaccine doses from Dr. Reddy’s lab, and the hospital staff would likely be inoculated first by the vaccine.

In India’s fight against Covid19, the Russian vaccine will go beyond pilot launch as a booster dose suited against the delta variant. Therefore, Sputnik V will be made available in several other Indian cities, including Mumbai, Bangalore and New Delhi, in addition to cities with its pilot run.

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Sputnik V will offer booster shot specifically against the Delta variant to other vaccine manufacturers. The makers of the Russian Covid-19 vaccine said that the booster shot will be “adjusted to work against the Delta variant of coronavirus, first detected in India.”

In this regard, Russian Direct Investment Fund (RDIF) said that the Sputnik V will soon be offering a booster shot. Russian scientists who developed Sputnik V have long advocated for vaccination combinations to improve efficacy.

Sputnik V vaccine, which has been developed in Russia, has been found to be more effective against the Delta variant of the Coronavirus. The delta variant, which found in India, is a highly transmissible variant of the Covid19-causing virus. It is important to note that the US CDC has classified the Delta variant, as a ‘variant of concern’.

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Sputnik V has been found to be more effective on the Delta variant than any other vaccine, as posted by Sputnik V’s official handle on Twitter.

Sputnik V was developed in Russia by Gamaleya Institute. The vaccine has reportedly showed over 91.6% efficacy against coronavirus, and it has been0 authorised in 67 countries across the world. On June 10, Russian Direct Investment Fund (RDIF) announced that the efficacy of the Sputnik V was estimated at 94.3% during a vaccination campaign by Bahrain’s Ministry of Health. World Health Organization (WHO) has not yet approved Sputnik V as an emergency vaccine. Argentina has claimed that Sputnik V has helped in saving millions of lives from the threat of Covid19. Hungary and Slovakia were the latest countries which authorised the emergency-use of Sputnik V vaccine.

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Other studies on efficacy of doses and third wave

A study by PGI Chandigarh claimed that the first dose of Covid-19 in India can be up to 75% effective. Another study said that the protection from Covishield’s first dose is 61% while both (first and second) doses are 65% effective. A sero-prevalence study was conducted among children of 2-17 years age from March 15 to June 10 by the World Health Organisation (WHO) and the All India Institute of Medical Sciences (AIIMS). The study showed that a third possible wave in India by the prevailing Covid-19 virus variant is unlikely to disproportionately affect children than adults.

Get revaccinated; US universities tell Indian students who took jabs of Covaxin & Sputnik V

COVID-19 vaccine

Many students of colleges and universities in US have been inoculated with India’s indigenous Covaxin or the Russian-made Sputnik V. Such students have been asked by the colleges and universities to get re-vaccinated with WHO- approved Covid-19 vaccines. More than 400 US colleges and universities had asked students to get vaccinated against Covid-19 ahead of the Autumn semester.

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Rukmini Callimachi reported in The New York Times the case of an Indian student at Columbia University. Milloni Doshi, a 25-year-old student from India is due to start her master’s degree this fall at Columbia University’s School of International and Public Affairs. She has been administered two doses of Covaxin.  Columbia University has told her that she will need to be revaccinated with a different vaccine once she arrives on campus.

Doshi wrote via a messaging app, “I am just concerned about taking two different vaccines. They said the application process would be the toughest part of the cycle, but it has really been all of this that has been uncertain and anxiety-inducing.”

Also Read: An uncertain wait for vaccines by India despite a liberalized regulatory framework

Various campuses are proposing different measures for vaccination. The more complicated scenario is if students received a vaccine that has not been approved by the WHO, like Sputnik-V or Covaxin. Many colleges & universities are proposing that those students will need to be revaccinated, which presents both medical and logistical conundrums. This has thrown Indian students into a dilemma, and they are growing frantic. Such students who need to be revaccinated fear if there would be any complications.

No data exists on whether combining vaccines from different companies is safe. That adds to the problem and breeds fear in the minds of the students. Kristen Nordlund, a spokesperson for the Centres for Disease Control and Prevention (CDC) said, “Since Covid-19 vaccines are not interchangeable, the safety and effectiveness of receiving two different Covid-19 vaccines have not been studied.”

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Nordlund also has a piece of advice for people vaccinated outside the US with a vaccine not authorised by WHO. He said that such people should wait for a minimum of 28 days before taking the first dose of one of the vaccines sanctioned by Food and Drug Administration (FDA).

American students have access to the Pfizer, Moderna and Johnson & Johnson made Jansen vaccines. These three vaccines out of the total eight have been authorised by the global health body. This is a disparity which could hinder colleges that have made it a major priority to retain international students. It must be noted that international students brought in close to USD 39 billion in tuition fees in the year before the pandemic, according to an analysis.

Terry W Hartle, senior vice president at the American Council on Education said, “Universities want to enroll international students because they add diversity to the campus community and they bring money. It is why this has been a subject of intense discussion.”

The situation is particularly challenging for Indian students. India sends around 200,000 international students to American colleges every year. It is becoming increasingly hard for students to secure an appointment for a vaccine that will be accepted by American campuses.

Sudhanshu Kaushik, who runs the North American Association of Indian Students, which is working to help fellow students, said, “Every day, we get 10 to 15 messages and inquiries, saying ‘What does this mean? How does this impact me?’”

Hannah Buxbaum is Indiana University’s vice president for international affairs. She said that the administrators of the institution are working overtime to answer the roughly 200 phone calls and 300 emails that are pouring in every day from the university’s roughly 6,000 students overseas.

She said, “Ringing off the hook does not begin to describe. There is no question that there is anxiety and concern among our international students.”

Many American universities are only accepting the students who have been vaccinated with a WHO-approved Covid-19 vaccine.  Many universities have been vague on how are they planning to deal with the logistical complexity of spacing out these unrelated vaccines, beyond saying that they planned to accommodate students undergoing this process.

Rukmini Callimachi wrote that at least six regional governments in India have announced emergency clinics in the past week to vaccine students going to US universities, in wake of mounting pressure from confused and anxious students.

Meanwhile, the situation for Indian students already present in US is a bit favourable. Hence, many Indian parents are in a rush to send their children for higher education to the United States. This is not only for a degree from a coveted college but also for vaccination against Covid-19. Each state in the US has its own plan for deciding which groups of people will be vaccinated first, as per the website of its national public health agency. Currently, in Alaska and Alabama, individuals aged 16 years and above are eligible for a vaccine, according to the respective state websites.

According to the Connecticut state website, “Beginning April 1st, all individuals 16 years of age and older who live, work, or attend school in Connecticut are eligible to receive a vaccine.”

Delhi-based Harpreet Singh is mother of Ujjawal Singh, 18, who recently got admitted to the Knox College, a Liberal arts college in Galesburg, Illinois. With a sigh of relief, she said, “I am glad to send my child out partly because of the ongoing vaccination drive in the US.” She added, “It seemed safe to send him as all my relatives in Canada and the US and their kids have got the vaccine.”

Addressing the students who aspire to study abroad, Adarsh Khandelwal, director, Collegify said, “For the next two-three years, the availability of vaccines and the medical support system will play an important role in deciding your study abroad plans and possibilities of choosing your location of settling down and studies.”

The unprecedented second wave has put thousands of Indian students who were planning to study abroad in limbo. As the country continues to reel under the second wave of infection with coronavirus, Indian borders are sealed barring some exceptions. Among Indian students, those who want to return to college and have valid visas are allowed to travel to most countries, including the US and the UK, the two most popular destinations for Indian students. But first-timers are struggling to get visas as most embassies are either shut or moving extremely slowly with limited staff.

Abhishek Nakhate, founder and CEO of UK-based educational consultancy Zoom Abroad explained that, the visa process has “become stricter in terms of screening and deciding the genuineness of the student.”

Inaction of GOI on vaccination

Neither Indian government invested in vaccine research, nor did it work to place orders with the global pharmaceutical giants like Pfizer, Moderna, and Johnson & Johnson. BJP, the ruling party at the centre and its ministers were busy with Bihar election last year and with elections in Assam, Kerala, TN, Puducherry and West Bengal this year.

While GOI trumpeted in a hubristic and unsolicited braggadocio that India was in the endgame of the pandemic, the second wave came and rattled the country. Delhi and cities in UP faced an acute crisis of Oxygen. That in turn led many people to steal Oxygen cylinders. Dead bodies were found floating in major rivers without proper cremation and dogs were seen nibbling away whatever they could land their jaws on. BJP-led centre did not invest an ounce of thought on the either the education of the school and college students within the country choked by the lockdowns or the problems faced by Indian students in the US universities.

With India staring into oblivion in terms of vaccination, interest in the US has risen among many parents and students in the country. But, it can be hoped that the situation improves after US president Joe Biden promised of distributing 75% of the excess vaccine doses of US with the world through Covax facility.

Also Read: US President Joe Biden announced vaccine distribution plans; Kamala Harris dialed New Delhi

The most perturbing fact is that the centre did not consider the impact of Covid19 on the students who go to universities around the world, especially when it had not ensured supply of WHO-approved vaccines within the country. Due to the unconcerned and lackadaisical approach of the central government in terms of getting people vaccinated, many Indian students of US universities are now caught between the devil and deep blue sea.

Vaccines approved by WHO under EUL

On December 31, 2020, the Pfizer/BioNtech Comirnaty vaccine was listed for WHO Emergency Use Listing (EUL). On February 16, 2021, the SII/Covishield and AstraZeneca/AZD1222 vaccines (developed by AstraZeneca/Oxford and manufactured by the State Institute of India and SK Bio respectively) were given EUL. On March 12, 2021, the Janssen/Ad26.COV 2.S developed by Johnson & Johnson, was listed for EUL. On April 30, 2021, the Moderna COVID-19 vaccine (mRNA 1273) was listed for EUL and on May 7, 2021 the Sinopharm COVID-19 vaccine was listed for EUL.

(With inputs from The NY times & WHO website)

Path from Vaccine maitri to waiting for Sputnik-V shipments from Russia- India set to receive first doses of Sputnik-V

As Covid-19 cases and deaths have surged in India, on Saturday, the country is set to receive its first doses of Sputnik-V, the Russian-made vaccine against the coronavirus disease. More than 300,000 new infections have been reported daily for nine days in a row, with 386,452 cases reported on Friday.

This delivery of Sputnik V is part of a larger partnership between Moscow and New Delhi to produce 850 million Sputnik vaccines. Priced at $10 a shot, this vaccine is a cheaper alternative to the Western substitutes. Further shipments could ease the current public health crisis, over the coming months, provided the government can administer the shots quickly.

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On March 11 the ‘Vaccine Maitri’ programme completed 50 days. By that time, India had supplied around 60 million doses of Made-in-India Covid vaccines to 70 countries across the world. The central government was slurping its fingers in self-adulation and an unabashed dose of hubris. By April end, the situation changed to a diametrically opposite situation. India is now looking forward to vaccine shipments from other countries.

Also Read: Issues faced by India in dealing with Covid 19 resurge- Is it too late to contain the Second Wave

Shortage of vaccines and a high infection rate will likely hamper vaccination efforts. The Sputnik deal, in the medium-term, along with other foreign aid, will likely curb the second wave by Autumn. The second wave of Coronavirus may also delay India’s economic recovery if the government re-imposes lockdown restrictions. There would be economic dampening if the variant spreads to other countries, prompting further outbreaks and lockdowns that damage global trade.

Far from being a self-reliant source of vaccine, the international image of India has been transformed into that of desperation. Any country’s vaccine manufacturing capabilities is measured by its flu-shot producing capacity and the agility with which it can be used for Covid19 vaccines. Seasonal flu is not a common vaccine in India and consequently share of India to the global output is at around 21%. That far away from what it takes to be self-reliant or the hubristic atma-nirbhar in vaccine production. The scenario in medical Oxygen production is even murkier.

Therefore, India is now waiting for shipments, and aid from other countries like Russia, US, and other powers from EU.